Article
Intranasal Infection of Ferrets with SARS-CoV-2 as a Model for Asymptomatic Human Infection.
Viruses - 15 Jan 2021
Everett Helen E, Lean Fabian Z X, Byrne Alexander M P, van Diemen Pauline M, Rhodes Shelley, James Joe, Mollett Benjamin, Coward Vivien J, Skinner Paul, Warren Caroline J, Bewley Kevin R, Watson Samantha, Hurley Shellene, Ryan Kathryn A, Hall Yper, Simmons Hugh, Núñez Alejandro, Carroll Miles W, Brown Ian H, Brookes Sharon M
Abstract excerpt
Ferrets were experimentally inoculated with SARS-CoV-2 (severe acute respiratory syndrome (SARS)-related coronavirus 2) to assess infection dynamics and host response. During the resulting subclinical infection, viral RNA was monitored between 2 and 21 days post-inoculation (dpi), and reached a peak in the upper respiratory cavity between 4 and 6 dpi. Viral genomic sequence analysis in samples from three animals...
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