Article
ESMO recommendations on the standard methods to detect RET fusions and mutations in daily practice and clinical research.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Mar 2021
Belli C, Penault-Llorca F, Ladanyi M, Normanno N, Scoazec J-Y, Lacroix L, Reis-Filho J S, Subbiah V, Gainor J F, Endris V, Repetto M, Drilon A, Scarpa A, André F, Douillard J-Y, Curigliano G
Abstract excerpt
Aberrant activation of RET is a critical driver of growth and proliferation in diverse solid tumours. Multikinase inhibitors (MKIs) showing anti-RET activities have been tested in RET-altered tumours with variable results. The low target specificity with consequent increase in side-effects and off-target toxicities resulting in dose reduction and drug discontinuation are some of the major issues with MKIs. To...
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