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A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein

12 Jan 2021

Abstract excerpt

Vaccines and therapeutics are urgently needed for the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we screen human monoclonal antibodies (mAb) targeting the receptor binding domain (RBD) of the viral spike protein via antibody library constructed from peripheral blood mononuclear cells of a convalescent patient. The CT-P59 mAb potently neutralizes SARS-CoV-2 isolates...

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PMID: 33436577
DOI: 10.1038/s41467-020-20602-5

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