Article
Lynch syndrome-associated repeated stroke with MLH1 frame-shift mutation.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 1 Apr 2021
Zhang Mengqi, Yang Haojun, Chen Zhuohui, Fan Yishu, Hu Xinhang, Liu Weiping
Abstract excerpt
Lynch syndrome (LS) is an autosomal dominant inherited disease caused by germline mutations in DNA mismatch repair (MMR) genes, including MLH1, MSH2, MSH6, and PMS2, which predisposes patients to various malignant neoplasms. Previous studies showed that MLH1, MSH2, MSH6, and PMS2 mutation in LS were associated with an elevated risk of colorectal, gastric, endometria, ovarian, and other cancers among family...
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