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Article

Universal Lynch Syndrome Screening Should be Performed in All Upper Tract Urothelial Carcinomas.

The American journal of surgical pathology - 1 Nov 2018

Ju Jennifer Y, Mills Anne M, Mahadevan Mani S, Fan Jinbo, Culp Stephen H, Thomas Martha H, Cathro Helen P

Abstract excerpt

Lynch syndrome (LS) is defined by germline mutations in DNA mismatch repair (MMR) genes, and affected patients are at high risk for multiple cancers. Reflexive testing for MMR protein loss by immunohistochemistry (IHC) is currently only recommended for colorectal and endometrial cancers, although upper tract urothelial carcinoma (UTUC) is the third-most common malignancy in patients with LS. To study the...

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Share to DNA Mismatch Repair
Share to DNA Repair Enzymes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Early Detection of Cancer

Share to Mismatch Repair Endonuclease PMS2

Share to MutL Protein Homolog 1

Share to MutS Homolog 2 Protein

Share to Urologic Neoplasms

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Source

Identifiers

PMID: 30148743
DOI: 10.1097/PAS.0000000000001141

Genes

MSH6
MLH1
PMS2
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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Universal Lynch Syndrome Screening Should be Performed in All Upper Tract Urothelial Carcinomas.PMID 30148743Read ↗

Clinicopathological characteristics of patients with upper urinary tract urothelial cancer with loss of immunohistochemical expression of the DNA mismatch repair proteins in universal screening.Semantic proximity Read ↗

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Genotype-Phenotype Characterization of Lynch Syndrome-associated Upper Tract Urothelial Carcinoma.Semantic proximity Read ↗

Lynch syndrome in upper tract urothelial carcinoma: significance, screening, and surveillance.Semantic proximity Read ↗

Patients with Lynch syndrome mismatch repair gene mutations are at higher risk for not only upper tract urothelial cancer but also bladder cancer.Semantic proximity Read ↗

Universal screening for Lynch syndrome in endometrial cancers: frequency of germline mutations and identification of patients with Lynch-like syndrome.Semantic proximity Read ↗

Lynch syndrome in the 21st century: clinical perspectives.Semantic proximity Read ↗

Lynch syndrome and urologic malignanciesSemantic proximity Read ↗

Estimating the prevalence of germline mutations in DNA mismatch repair genes among patients with upper tract urothelial carcinoma: a systematic review and meta-analysis.Semantic proximity Read ↗

Lynch Syndrome Screening Should Be Considered for All Patients With Newly Diagnosed Endometrial CancerSemantic proximity Read ↗

Incidence and molecular characteristics of deficient mismatch repair conditions across nine different tumors and identification of germline variants involved in Lynch-like syndromeSemantic proximity Read ↗

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