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Article

Association Between the Angiotensin-Converting Enzyme I/D Polymorphism and Risk of Cerebral Small Vessel Disease: A Meta-Analysis Based on 7186 Subjects.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 1 Mar 2021

Su Cheng, Liu Wen-Chen, Li Guo-Ming, Huang Yan

Abstract excerpt

INTRODUCTION: Cerebral small vessel disease (CSVD) causes a quarter of all strokes and is the most common pathology underlying vascular dementia. However, the mechanism of CSVD remains unclear. Numerous studies have investigated whether the angiotensin-converting enzyme (ACE) intersection/deletion (I/D) polymorphism influences the risk of CSVD, but the results are controversial. METHODS: We searched English and...

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PMID: 33412396
DOI: 10.1016/j.jstrokecerebrovasdis.2020.105579

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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