Vulnerability to low-dose combination of irinotecan and niraparib in ATM-mutated colorectal cancer.

doi:10.1186/s13046-020-01811-8

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Article

Vulnerability to low-dose combination of irinotecan and niraparib in ATM-mutated colorectal cancer.

Journal of experimental & clinical cancer research : CR - 6 Jan 2021

Vitiello Pietro Paolo, Martini Giulia, Mele Luigi, Giunta Emilio Francesco, De Falco Vincenzo, Ciardiello Davide, Belli Valentina, Cardone Claudia, Matrone Nunzia, Poliero Luca, Tirino Virginia, Napolitano Stefania, Della Corte Carminia, Selvaggi Francesco, Papaccio Gianpaolo, Troiani Teresa, Morgillo Floriana, Desiderio Vincenzo, Ciardiello Fortunato, Martinelli Erika

Abstract excerpt

BACKGROUND: Despite the advancements in new therapies for colorectal cancer (CRC), chemotherapy still constitutes the mainstay of the medical treatment. For this reason, new strategies to increase the efficacy of chemotherapy are desirable. Poly-ADP-Ribose Polymerase inhibitors (PARPi) have shown to increase the activity of DNA damaging chemotherapeutics used in the treatment of CRC, however previous clinical...

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PMID: 33407715
DOI: 10.1186/s13046-020-01811-8
PMCID: PMC7789007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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