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Article

The Status of EGFR Modulates the Effect of miRNA-200c on ZEB1 Expression and Cell Migration in Glioblastoma Cells.

International journal of molecular sciences - 31 Dec 2020

Muñoz-Hidalgo Lisandra, San-Miguel Teresa, Megías Javier, Serna Eva, Calabuig-Fariñas Silvia, Monleón Daniel, Gil-Benso Rosario, Cerdá-Nicolás Miguel, López-Ginés Concha

Abstract excerpt

Migration of glioblastoma cells into surrounding tissue is one of the main features that makes this tumor incurable. We evaluated whole-genome miRNA expression profiling associated with different EGFR amplification patterns in 30 cases of primary glioblastoma. From the 64 miRNAs that showed differential expression between tumors with a high level of EGFR amplification and tumors without EGFR amplification, 40%...

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Identifiers

PMID: 33396457
DOI: 10.3390/ijms22010368
PMCID: PMC7795155

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