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Article

Extensive functional evaluation of exon 20 insertion mutations of EGFR.

Lung cancer (Amsterdam, Netherlands) - 1 Feb 2021

Hirose Takeshi, Ikegami Masachika, Endo Makoto, Matsumoto Yoshihiro, Nakashima Yasuharu, Mano Hiroyuki, Kohsaka Shinji

Abstract excerpt

OBJECTIVES: Exon 20 insertion mutations of epidermal growth factor receptor (EGFR) have been identified as oncogenic mutations in general; however, the functional relevance of each remains largely uninvestigated. Herein, we comprehensively assessed the functional significance of insertion mutations of EGFR exon 20. MATERIALS AND METHODS: The transforming potential and drug sensitivities of 25 EGFR recurrent...

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Identifiers

PMID: 33395611
DOI: 10.1016/j.lungcan.2020.12.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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