Article
Ethanol Gestational Exposure Impairs Vascular Development and Endothelial Potential to Control BBB-Associated Astrocyte Function in the Developing Cerebral Cortex.
Molecular neurobiology - 1 Apr 2021
Siqueira Michele, Araujo Ana Paula Bérgamo, Gomes Flávia Carvalho Alcantara, Stipursky Joice
Abstract excerpt
Ethanol consumption during pregnancy or lactation period can induce permanent damage to the development of the central nervous system (CNS), resulting in fetal alcohol spectrum disorders (FASD). CNS development depends on proper neural cells and blood vessel (BV) development and blood-brain barrier (BBB) establishment; however, little is known about how ethanol affects these events. Here, we investigated the...
Topics
- Animals
- Animals, Newborn
- Astrocytes
- Blood Vessels
- Blood-Brain Barrier
- Cerebral Cortex
- Endothelial Cells
- Ethanol
- Female
- Fetal Alcohol Spectrum Disorders
- Gene Expression Profiling
- Gene Expression Regulation
- Humans
- Mice