Article
Sex and Exposure to Postnatal Chlorpyrifos Influence the Epigenetics of Feeding-Related Genes in a Transgenic APOE Mouse Model: Long-Term Implications on Body Weight after a High-Fat Diet.
International journal of environmental research and public health - 29 Dec 2020
Guardia-Escote Laia, Blanco Jordi, Basaure Pia, Biosca-Brull Judit, Verkaik-Schakel Rikst Nynke, Cabré Maria, Peris-Sampedro Fiona, Pérez-Fernández Cristian, Sánchez-Santed Fernando, Plösch Torsten, Domingo José L, Colomina Maria Teresa
Abstract excerpt
Developmental exposure to toxicants and diet can interact with an individual's genetics and produce long-lasting metabolic adaptations. The different isoforms of the apolipoprotein E (APOE) are an important source of variability in metabolic disorders and influence the response to the pesticide chlorpyrifos (CPF). We aimed to study the epigenetic regulation on feeding control genes and the influence of postnatal...
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