Article
Multicenter Next-Generation Sequencing Studies between Theory and Practice: Harmonization of Data Analysis Using Real-World Myelodysplastic Syndrome Data.
The Journal of molecular diagnostics : JMD - 1 Mar 2021
Sandmann Sarah, de Graaf Aniek O, Tobiasson Magnus, Kosmider Olivier, Abáigar María, Clappier Emmanuelle, Gallì Anna, van der Reijden Bert A, Malcovati Luca, Fenaux Pierre, Díez-Campelo María, Fontenay Michaela, Hellström-Lindberg Eva, Jansen Joop H, Dugas Martin
Abstract excerpt
In the age of personalized medicine, genetic testing by means of targeted sequencing has taken a key role. However, when comparing different sets of targeted sequencing data, these are often characterized by a considerable lack of harmonization. Laboratories follow their own best practices, analyzing their own target regions. The question on how to best integrate data from different sites remains unanswered....
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