Article
HLA-DRB1* and DQB1* allele and haplotype diversity in eight tribal populations: Global affinities and genetic basis of diseases in South India.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Apr 2021
Rangasamy Nandakumar, Chinniah Rathika, Ravi Padma-Malini, Vijayan Murali, Sivanadham Ramgopal, K V Darsa, Pandi Sasiharan, Sevak Vandit, Krishnan Prabhakaran, Karuppiah Balakrishnan
Abstract excerpt
The distribution of HLA class-II DRB1* and DQB1* alleles/ haplotypes were studied in 438 individuals of 8 Dravidian tribal groups inhabiting the Western Ghats, south India. The HLA typing was performed by PCR-SSP method. In order to identify the 5-locus Ancestral Extended Haplotypes (AEH), the alleles of HLA-A, -B and -C loci were typed for DNAs with predominant 2-locus haplotypes. The analyses have revealed...
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