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Genetic architecture of host proteins involved in SARS-CoV-2 infection

16 Dec 2020

Abstract excerpt

Understanding the genetic architecture of host proteins interacting with SARS-CoV-2 or mediating the maladaptive host response to COVID-19 can help to identify new or repurpose existing drugs targeting those proteins. We present a genetic discovery study of 179 such host proteins among 10,708 individuals using an aptamer-based technique. We identify 220 host DNA sequence variants acting in cis (MAF 0.01-49.9%)...

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PMID: 33328453
DOI: 10.1038/s41467-020-19996-z

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