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An association study between MiR-146a and INSR gene polymorphisms and hypertensive disorders of pregnancy in Northeastern Han Chinese population.

Placenta - 15 Jan 2021

Lu Rui, Liu Nana, Feng Xiu, Feng Yanan, Zhang Shuang, Wu Yingnan, Jia Tianshuang, Yang Xuan, Lee Leo Tsz On, Sun Litao

Abstract excerpt

INTRODUCTION: Hypertensive disorders of pregnancy(HDP) is a complex and challenging group of pregnancy complications that is one of the leading causes of maternal and fetal death worldwide. Recent studies have shown that the single nucleotide polymorphism(SNP) may play a role in the pathogenesis of HDP. This study aimed to investigate the association of MiR-146a rs2910164 and insulin receptor(INSR) rs2059806 SNPs...

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PMID: 33310299
DOI: 10.1016/j.placenta.2020.11.011

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