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Article

A Perspective on Personalized Therapies in Hypertrophic Cardiomyopathy.

Journal of cardiovascular pharmacology - 1 Mar 2021

Goldspink Paul H, Warren Chad M, Kitajewski Jan, Wolska Beata M, Solaro R John

Abstract excerpt

ABSTRACT: A dominant mechanism of sudden cardiac death in the young is the progression of maladaptive responses to genes encoding proteins linked to hypertrophic cardiomyopathy. Most are mutant sarcomere proteins that trigger the progression by imposing a biophysical defect on the dynamics and levels of myofilament tension generation. We discuss approaches for personalized treatments that are indicated by recent...

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Identifiers

PMID: 33298734
DOI: 10.1097/FJC.0000000000000968
PMCID: PMC7933064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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