miRNA-506-3p Directly Regulates rs10754339 (A/G) in the Immune Checkpoint Protein B7-H4 in Breast Cancer.

doi:10.2174/2211536609666201209152949

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miRNA-506-3p Directly Regulates rs10754339 (A/G) in the Immune Checkpoint Protein B7-H4 in Breast Cancer.

MicroRNA (Shariqah, United Arab Emirates) - 1 Jan 2020

El Din Germine Saad, Youness Rana Ahmed, Assal Reem Amr, Gad Mohamed Zakaria

Abstract excerpt

BACKGROUND: B7-H4 is a novel immune checkpoint protein that negatively regulates T cell activation and function. It is overexpressed in many malignant tumors, including Breast Cancer (BC). It was reported that the presence of the single nucleotide polymorphism rs10754339 (A/G) within the 3' UTR of the B7-H4 gene has a great influence on the risk and progression of BC as well as lymph node metastasis. On the other...

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PMID: 33297930
DOI: 10.2174/2211536609666201209152949

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