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Identification of "regulation of RhoA activity panel" as a prognostic and predictive biomarker for gastric cancer.

Aging - 3 Dec 2020

Huang Wenwen, Zhao Songhui, Zhang Cheng, Li Zhongwu, Ge Sai, Lian Baofeng, Feng Hui, Wang Kai, Xu Ruihua, Ji Jiafu, Gao Jing, Shi Weiwei, Shen Lin

Abstract excerpt

RhoA is a member of the RHO family GTPases and is associated with essential functions in gastric cancer. In this study, we identified a gastric cancer biomarker, termed the "regulation of RhoA activity panel" (RRAP). Patients with gastric cancer from The Cancer Genome Atlas database were divided into training (N=160) and validation (N=155) cohorts. A cohort of 109 Chinese gastric cancer patients was utilized as...

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PMID: 33288739
DOI: 10.18632/aging.202179
PMCID: PMC7835016

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