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Article

Targeting female flight for genetic control of mosquitoes.

PLoS neglected tropical diseases - 1 Dec 2020

Navarro-Payá David, Flis Ilona, Anderson Michelle A E, Hawes Philippa, Li Ming, Akbari Omar S, Basu Sanjay, Alphey Luke

Abstract excerpt

Aedes aegypti Act4 is a paralog of the Drosophila melanogaster indirect flight muscle actin gene Act88F. Act88F has been shown to be haploinsufficient for flight in both males and females (amorphic mutants are dominant). Whereas Act88F is expressed in indirect flight muscles of both males and females, expression of Act4 is substantially female-specific. We therefore used CRISPR/Cas9 and homology directed repair...

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Identifiers

PMID: 33270627
DOI: 10.1371/journal.pntd.0008876
PMCID: PMC7714197

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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