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Article

Copy number gain of pro-inflammatory genes in patients with HBV-related acute-on-chronic liver failure.

BMC medical genomics - 1 Dec 2020

Sun Fengming, Tan Wenting, Dan Yunjie, Wang Xiuhua, Guo Yanzhi, Deng Guohong

Abstract excerpt

BACKGROUND: Host genetic factors such as single nucleotide variations may play a crucial role in the onset and progression of HBV-related acute-on-chronic liver failure (ACLF). However, the underlying genomic copy number variations (CNVs) involved in the pathology are currently unclear. METHODS: We genotyped two cohorts with 389 HBV-related ACLF patients and 391 asymptomatic HBV carriers (AsCs), and then carried...

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Identifiers

PMID: 33261607
DOI: 10.1186/s12920-020-00835-5
PMCID: PMC7709420

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