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Article

Inborn errors of thymic stromal cell development and function

30 Nov 2020

Abstract excerpt

As the primary site for T cell development, the thymus is responsible for the production and selection of a functional, yet self-tolerant T cell repertoire. This critically depends on thymic stromal cells, derived from the pharyngeal apparatus during embryogenesis. Thymic epithelial cells, mesenchymal and vascular elements together form the unique and highly specialised microenvironment required to support all...

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PMID: 33257998
DOI: 10.1007/s00281-020-00826-9

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