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Article

An epigenome-wide association study of metabolic syndrome and its components.

Scientific reports - 25 Nov 2020

Nuotio Marja-Liisa, Pervjakova Natalia, Joensuu Anni, Karhunen Ville, Hiekkalinna Tero, Milani Lili, Kettunen Johannes, Järvelin Marjo-Riitta, Jousilahti Pekka, Metspalu Andres, Salomaa Veikko, Kristiansson Kati, Perola Markus

Abstract excerpt

The role of metabolic syndrome (MetS) as a preceding metabolic state for type 2 diabetes and cardiovascular disease is widely recognised. To accumulate knowledge of the pathological mechanisms behind the condition at the methylation level, we conducted an epigenome-wide association study (EWAS) of MetS and its components, testing 1187 individuals of European ancestry for approximately 470 000 methylation sites...

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PMID: 33239708
DOI: 10.1038/s41598-020-77506-z
PMCID: PMC7688654

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