Article
The Arabidopsis V-ATPase is localized to the TGN/EE via a seed plant-specific motif.
eLife - 25 Nov 2020
Lupanga Upendo, Röhrich Rachel, Askani Jana, Hilmer Stefan, Kiefer Christiane, Krebs Melanie, Kanazawa Takehiko, Ueda Takashi, Schumacher Karin
Abstract excerpt
The V-ATPase is a versatile proton-pump found in a range of endomembrane compartments yet the mechanisms governing its differential targeting remain to be determined. In Arabidopsis, VHA-a1 targets the V-ATPase to the TGN/EE whereas VHA-a2 and VHA-a3 are localized to the tonoplast. We report here that the VHA-a1 targeting domain serves as both an ER-exit and as a TGN/EE-retention motif and is conserved among seed...
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