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Inflammasomes and Childhood Autoimmune Diseases: A Review of Current Knowledge.

Clinical reviews in allergy & immunology - 1 Oct 2021

Yang Chin-An, Chiang Bor-Luen

Abstract excerpt

Inflammasomes are multiprotein complexes capable of sensing pathogen-associated molecular patterns (PAMPs), danger-associated molecular patterns (DAMPs), and cellular perturbations. Upon stimulation, the inflammasomes activate the production of the pro-inflammatory cytokines IL-1β and IL-18 and induce gasdermin D-mediated pyroptosis. Dysregulated inflammasome signaling could lead to hyperinflammation in response...

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Autoimmune Diseases
Autoimmunity
Child
Cytokines
Inflammasomes
Mutation

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Rheumatic Diseases

Signal Transduction

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PMID: 33236284
DOI: 10.1007/s12016-020-08825-2
PMCID: PMC7685913

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