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A peptide of a type I toxin−antitoxin system induces Helicobacter pylori morphological transformation from spiral shape to coccoids

23 Nov 2020

Abstract excerpt

Significance Helicobacter pylori , a gastric pathogen causing 800,000 deaths in the world annually, is encountered both in vitro and in patients as spiral-shaped bacteria and as round cells named coccoids. We discovered that the toxin from a chromosomal type I toxin−antitoxin system is targeting H. pylori membrane and acting as an effector of H. pylori morphological conversion to coccoids. We show that these...

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PMID: 33229580
DOI: 10.1073/pnas.2016195117

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