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Article

Elevated Polygenic Burden for Autism Spectrum Disorder Is Associated With the Broad Autism Phenotype in Mothers of Individuals With Autism Spectrum Disorder.

Biological psychiatry - 1 Mar 2021

Nayar Kritika, Sealock Julia M, Maltman Nell, Bush Lauren, Cook Edwin H, Davis Lea K, Losh Molly

Abstract excerpt

BACKGROUND: Autism spectrum disorder (ASD) is a multifactorial neurodevelopmental disorder that encompasses a complex and heterogeneous set of traits. Subclinical traits that mirror the core features of ASD, referred to as the broad autism phenotype (BAP), have been documented repeatedly in unaffected relatives and are believed to reflect underlying genetic liability to ASD. The BAP may help inform the etiology...

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PMID: 33229037
DOI: 10.1016/j.biopsych.2020.08.029
PMCID: PMC7901138

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