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Identification of contributing genes of Huntington’s disease by machine learning

23 Nov 2020

Abstract excerpt

BACKGROUND: Huntington's disease (HD) is an inherited disorder caused by the polyglutamine (poly-Q) mutations of the HTT gene results in neurodegeneration characterized by chorea, loss of coordination, cognitive decline. However, HD pathogenesis is still elusive. Despite the availability of a wide range of biological data, a comprehensive understanding of HD's mechanism from machine learning is so far unrealized,...

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PMID: 33228685
DOI: 10.1186/s12920-020-00822-w

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