Article
Pathogenic Differences of Type 1 Restriction-Modification Allele Variants in Experimental Listeria monocytogenes Meningitis.
Frontiers in cellular and infection microbiology - 1 Jan 2020
Zbinden Florian R, De Ste Croix Megan, Grandgirard Denis, Haigh Richard D, Vacca Irene, Zamudio Roxana, Goodall Emily C A, Stephan Roger, Oggioni Marco R, Leib Stephen L
Abstract excerpt
Background:L. monocytogenes meningoencephalitis has a mortality rate of up to 50% and neurofunctional sequelae are common. Type I restriction-modification systems (RMS) are capable of adding methyl groups to the host genome. Some contain multiple sequence recognition (hsdS) genes that recombine, resulting in distinct DNA methylation patterns and patterns of gene expression. These phenotypic switches have been...
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