Article
Plasma Insulin-like Growth Factor Binding Protein 7 Contributes Causally to ARDS 28-Day Mortality: Evidence From Multistage Mendelian Randomization.
Chest - 1 Mar 2021
Dong Xuesi, Zhu Zhaozhong, Wei Yongyue, Ngo Debby, Zhang Ruyang, Du Mulong, Huang Hui, Lin Lijuan, Tejera Paula, Su Li, Chen Feng, Ahasic Amy M, Thompson B Taylor, Meyer Nuala J, Christiani David C
Abstract excerpt
BACKGROUND: ARDS is a devastating syndrome with heterogeneous subtypes, but few causal biomarkers have been identified. RESEARCH QUESTION: Would multistage Mendelian randomization identify new causal protein biomarkers for ARDS 28-day mortality? STUDY DESIGN AND METHODS: Three hundred moderate to severe ARDS patients were selected randomly from the Molecular Epidemiology of ARDS cohort for proteomics analysis....
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