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Article

Novel Resistance Mechanisms Including L1196Q, P1094H, and R1248_D1249 Insertion in Three Patients With NSCLC After ALK Tyrosine Kinase Inhibitor Treatment.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Mar 2021

Furuta Hiromi, Araki Mitsugu, Masago Katsuhiro, Sagae Yukari, Fujita Shiro, Seto Katsutoshi, Shimizu Junichi, Horio Yoshitsugu, Sasaki Eiichi, Hosoda Waki, Katayama Ryohei, Okuno Yasushi, Hida Toyoaki

Abstract excerpt

OBJECTIVES: The purposes of this study are to clarify the details of the ALK tyrosine kinase inhibitor (TKI) resistance mechanism in rebiopsy cases and to predict novel resistance gene alterations using molecular dynamics simulation. METHODS: A total of 21 patients with ALK-positive NSCLC who underwent a rebiopsy after ALK TKI failure were included in this analysis. ALK fluorescence in situ hybridization and...

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Share to Anaplastic Lymphoma Kinase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 33166721
DOI: 10.1016/j.jtho.2020.09.023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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