Article
Impact of ERCC1 gene polymorphisms on response to cisplatin based therapy in oral squamous cell carcinoma (OSCC) patients.
Indian journal of pathology & microbiology - 1 Jan 2000
Avinash Tejasvi M L, Maragathavalli G, Putcha Uday Kumar, Ramakrishna M, Vijayaraghavan R, Anulekha Avinash C K
Abstract excerpt
BACKGROUND AND OBJECTIVES: Cisplatin is one of the major drugs that used in the treatment of oral cancer.Excision repair cross-complementation group 1 (ERCC1) is a key DNA repair gene in the nucleotide excision repair pathway which is activated in the repair of intra- and interstrand DNA crosslink caused by platinum-based treatment. The aim of this study was to investigate the association between polymorphisms in...
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