Identification of GII.14[P7] norovirus and its genomic mutations from a case of long-term infection in a post-symptomatic individual.

doi:10.1016/j.meegid.2020.104612

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Article

Identification of GII.14[P7] norovirus and its genomic mutations from a case of long-term infection in a post-symptomatic individual.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Dec 2020

Nonthabenjawan Nutthawan, Boonyos Patcharaporn, Phattanawiboon Benjarat, Towayunanta Worakarn, Chuntrakool Kobkool, Ngaopravet Karn, Ruchusatsawat Kriangsak, Uppapong Ballang, Sangkitporn Somchai, Mekada Eisuke, Matsuura Yoshiharu, Tatsumi Masashi, Mizushima Hiroto

Abstract excerpt

Norovirus is a leading cause of acute gastroenteritis worldwide. Norovirus shedding typically lasts one week to one month after the onset of diarrhea in immunocompetent hosts. The occurrence of mutations in the genome during infection has contributed to the evolution of norovirus. It has been suggested that genomic mutations in the P2-domain of capsid protein VP1, the major antigenic site for virus clearance, are...

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PMID: 33137471
DOI: 10.1016/j.meegid.2020.104612

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