Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season.

doi:10.1038/s41591-020-1084-0

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Article

Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season.

Nature medicine - 1 Dec 2020

Andrade Carolina M, Fleckenstein Hannah, Thomson-Luque Richard, Doumbo Safiatou, Lima Nathalia F, Anderson Carrie, Hibbert Julia, Hopp Christine S, Tran Tuan M, Li Shanping, Niangaly Moussa, Cisse Hamidou, Doumtabe Didier, Skinner Jeff, Sturdevant Dan, Ricklefs Stacy, Virtaneva Kimmo, Asghar Muhammad, Homann Manijeh Vafa, Turner Louise, Martins Joana, Allman Erik L, N'Dri Marie-Esther, Winkler Volker, Llinás Manuel, Lavazec Catherine, Martens Craig, Färnert Anna, Kayentao Kassoum, Ongoiba Aissata, Lavstsen Thomas, Osório Nuno S, Otto Thomas D, Recker Mario, Traore Boubacar, Crompton Peter D, Portugal Silvia

Abstract excerpt

The dry season is a major challenge for Plasmodium falciparum parasites in many malaria endemic regions, where water availability limits mosquito vectors to only part of the year. How P. falciparum bridges two transmission seasons months apart, without being cleared by the human host or compromising host survival, is poorly understood. Here we show that low levels of P. falciparum parasites persist in the blood...

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PMID: 33106664
DOI: 10.1038/s41591-020-1084-0

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