Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Proteolytic Network in Palmoplantar Keratoderma: SERPINA12 Joins the Family.

The Journal of investigative dermatology - 1 Nov 2020

Steele Lloyd, Tawfik Soha S, O'Toole Edel A

Abstract excerpt

Mohamad et al. (2020) describe loss-of-function mutations in SERPINA12 as a cause of diffuse, transgradient palmoplantar keratoderma (PPK). This disorder shares similar clinical features with other PPKs caused by protease overactivity, including erythema, peeling, and exacerbation on water exposure. Understanding this disorder may shed further light on the role of proteases and their inhibitors in epidermal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epidermis
Share to Keratoderma, Palmoplantar
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Peptide Hydrolases

Share to Proteolysis

Share to Serpins

Source

Identifiers

PMID: 33099397
DOI: 10.1016/j.jid.2020.06.031

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Proteolytic Network in Palmoplantar Keratoderma: SERPINA12 Joins the Family.PMID 33099397Read ↗

Loss-of-Function Variants in SERPINA12 Underlie Autosomal Recessive Palmoplantar Keratoderma.Semantic proximity Read ↗

A novel SERPINA12 variant and first European patients with diffuse palmoplantar keratoderma.Semantic proximity Read ↗

Mutations in SERPINB7, encoding a member of the serine protease inhibitor superfamily, cause Nagashima-type palmoplantar keratosis.Semantic proximity Read ↗

Nagashima-Type Palmoplantar Keratosis: Clinical Characteristics, Genetic Characterization, and Clinical Management.Semantic proximity Read ↗

Large-Scale Cohort Study on the Genetic and Phenotypic Findings of Palmoplantar Keratodermas in the Chinese Population.Semantic proximity Read ↗

The palmoplantar keratodermas: much more than palms and soles.Semantic proximity Read ↗

History and prospects of Nagashima‐type palmoplantar keratosis, the most common palmoplantar keratoderma in east Asian populationsSemantic proximity Read ↗

Proteases: common culprits in human skin disordersSemantic proximity Read ↗

Dysregulated proteolytic cascades in Netherton syndrome: from molecular pathology to preclinical drug testing.Semantic proximity Read ↗

Investigation of Nagashima-type palmoplantar keratoderma in China: A cross-sectional study of 234 patients.Semantic proximity Read ↗

Diagnosis and Management of Inherited Palmoplantar Keratodermas.Semantic proximity Read ↗

Palmoplantar keratoderma (PPK): acquired and genetic causes of a not so rare disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.