Article
rad21 Is Involved in Corneal Stroma Development by Regulating Neural Crest Migration.
International journal of molecular sciences - 21 Oct 2020
Zhang Bi Ning, Liu Yu, Yang Qichen, Leung Pui Ying, Wang Chengdong, Wong Thomas Chi Bun, Tham Clement C, Chan Sun On, Pang Chi Pui, Chen Li Jia, Dekker Job, Zhao Hui, Chu Wai Kit
Abstract excerpt
Previously, we identified RAD21R450C from a peripheral sclerocornea pedigree. Injection of this rad21 variant mRNA into Xenopus laevis embryos disrupted the organization of corneal stroma fibrils. To understand the mechanisms of RAD21-mediated corneal stroma defects, gene expression and chromosome conformation analysis were performed using cells from family members affected by peripheral sclerocornea. Both gene...
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