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Article

Phenotypic Discovery of an Antivirulence Agent against Vibrio vulnificus via Modulation of Quorum-Sensing Regulator SmcR.

ACS infectious diseases - 13 Nov 2020

Kim Seung Min, Park Jongmin, Kim Myun Soo, Song Heebum, Jo Ala, Park Hankum, Kim Tae Sung, Choi Sang Ho, Park Seung Bum

Abstract excerpt

An antivirulence agent against Vibrio vulnificus named quoromycin (QM) was discovered by a phenotype-based elastase inhibitor screening. Using the fluorescence difference in two-dimensional gel electrophoresis (FITGE) approach, SmcR, a quorum-sensing master regulator and homologue of LuxR, was identified as the target protein of QM. We confirmed that the direct binding of QM to SmcR inhibits the quorum-sensing...

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PMID: 33086782
DOI: 10.1021/acsinfecdis.0c00587

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