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Role and mechanism of DNA methylation and its inhibitors in hepatic fibrosis

28 Mar 2023

Abstract excerpt

Liver fibrosis is a repair response to injury caused by various chronic stimuli that continually act on the liver. Among them, the activation of hepatic stellate cells (HSCs) and their transformation into a myofibroblast phenotype is a key event leading to liver fibrosis, however the mechanism has not yet been elucidated. The molecular basis of HSC activation involves changes in the regulation of gene expression...

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Share to Epigenetics and DNA Methylation
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PMID: 37056286
DOI: 10.3389/fgene.2023.1124330

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