Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of Damaging Variants in Genes With Increased Cancer Risk Among Patients With Congenital Heart Disease.

JAMA cardiology - 1 Apr 2021

Morton Sarah U, Shimamura Akiko, Newburger Peter E, Opotowsky Alexander R, Quiat Daniel, Pereira Alexandre C, Jin Sheng Chih, Gurvitz Michelle, Brueckner Martina, Chung Wendy K, Shen Yufeng, Bernstein Daniel, Gelb Bruce D, Giardini Alessandro, Goldmuntz Elizabeth, Kim Richard W, Lifton Richard P, Porter George A, Srivastava Deepak, Tristani-Firouzi Martin, Newburger Jane W, Seidman J G, Seidman Christine E

Abstract excerpt

Importance: Patients with congenital heart disease (CHD), the most common birth defect, have increased risks for cancer. Identification of the variables that contribute to cancer risk is essential for recognizing patients with CHD who warrant longitudinal surveillance and early interventions. Objective: To compare the frequency of damaging variants in cancer risk genes among patients with CHD and control...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Genes, Neoplasm

Share to Heart Defects, Congenital

Share to Infant

Share to Infant, Newborn

Share to Loss of Function Mutation

Share to Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 33084842
DOI: 10.1001/jamacardio.2020.4947
PMCID: PMC7578917

Genes

ARHGEF12
CTNNB1
LPP
PTEN
TCF12
TFRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of Damaging Variants in Genes With Increased Cancer Risk Among Patients With Congenital Heart Disease.PMID 33084842Read ↗

Genetics of congenital heart disease: the contribution of the noncoding regulatory genome.Semantic proximity Read ↗

Genetics of Congenital Heart Disease.Semantic proximity Read ↗

Assessing the contribution of rare variants to congenital heart disease through a large-scale case-control exome studySemantic proximity Read ↗

Genomic analysis of 11,555 probands identifies 60 dominant congenital heart disease genesSemantic proximity Read ↗

Targeted next-generation sequencing identifies pathogenic variants in familial congenital heart disease.Semantic proximity Read ↗

Genetic and Environmental Contributors To Congenital Heart DiseaseSemantic proximity Read ↗

Complex genetics and the etiology of human congenital heart disease.Semantic proximity Read ↗

Genetic Diagnostic Yield and Novel Causal Genes of Congenital Heart DiseaseSemantic proximity Read ↗

Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands.Semantic proximity Read ↗

Molecular diagnoses and candidate gene identification in the congenital heart disease cohorts of the 100,000 genomes projectSemantic proximity Read ↗

MEF2C loss-of-function mutation contributes to congenital heart defects.Semantic proximity Read ↗

In-Depth Genomic Analysis: The New Challenge in Congenital Heart DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.