Article
A de novo frameshift mutation in ZEB2 causes polledness, abnormal skull shape, small body stature and subfertility in Fleckvieh cattle.
Scientific reports - 12 Oct 2020
Gehrke Lilian J, Upadhyay Maulik, Heidrich Kristin, Kunz Elisabeth, Klaus-Halla Daniela, Weber Frank, Zerbe Holm, Seichter Doris, Graf Alexander, Krebs Stefan, Blum Helmut, Capitan Aurélien, Thaller Georg, Medugorac Ivica
Abstract excerpt
Polledness in cattle is an autosomal dominant trait. Previous studies have revealed allelic heterogeneity at the polled locus and four different variants were identified, all in intergenic regions. In this study, we report a case of polled bull (FV-Polled1) born to horned parents, indicating a de novo origin of this polled condition. Using 50K genotyping and whole genome sequencing data, we identified on...
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