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Identification and validation of methylation-driven genes prognostic signature for recurrence of laryngeal squamous cell carcinoma by integrated bioinformatics analysis

29 Sept 2020

Abstract excerpt

BACKGROUND: Recurrence remains a major obstacle to long-term survival of laryngeal squamous cell carcinoma (LSCC). We conducted a genome-wide integrated analysis of methylation and the transcriptome to establish methylation-driven genes prognostic signature (MDGPS) to precisely predict recurrence probability and optimize therapeutic strategies for LSCC. METHODS: LSCC DNA methylation datasets and RNA sequencing...

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Share to Epigenetics and DNA Methylation
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PMID: 33005105
DOI: 10.1186/s12935-020-01567-3

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