Article
Androgen derivatives improve blood counts and elongate telomere length in adult cryptic dyskeratosis congenita.
British journal of haematology - 1 May 2021
Kirschner Martin, Vieri Margherita, Kricheldorf Kim, Ferreira Monica S Ventura, Wlodarski Marcin W, Schwarz Michaela, Balabanov Stefan, Rolles Benjamin, Isfort Susanne, Koschmieder Steffen, Höchsmann Britta, Panse Jens, Brümmendorf Tim H, Beier Fabian
Abstract excerpt
Dyskeratosis Congenita (DKC) is a systemic disorder caused by mutations resulting in impaired telomere maintenance. Clinical features include bone marrow failure and an increased risk of developing hematological malignancies. There are conflicting data whether androgen derivatives (AD) can elongate telomeres in vivo and whether AD treatment enhances the risk of gaining myelodysplastic syndrome-related mutations....
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