Article
Dynamically evolving novel overlapping gene as a factor in the SARS-CoV-2 pandemic.
eLife - 1 Oct 2020
Nelson Chase W, Ardern Zachary, Goldberg Tony L, Meng Chen, Kuo Chen-Hao, Ludwig Christina, Kolokotronis Sergios-Orestis, Wei Xinzhu
Abstract excerpt
Understanding the emergence of novel viruses requires an accurate and comprehensive annotation of their genomes. Overlapping genes (OLGs) are common in viruses and have been associated with pandemics but are still widely overlooked. We identify and characterize ORF3d, a novel OLG in SARS-CoV-2 that is also present in Guangxi pangolin-CoVs but not other closely related pangolin-CoVs or bat-CoVs. We then document...
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