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Potential for Virus Endogenization in Humans through Testicular Germ Cell Infection: the Case of HIV

25 Sept 2020

Abstract excerpt

Viruses have colonized the host germ line on many occasions during evolution to eventually become endogenous. Here, we aimed at investigating whether human testicular germ cells (TGCs) can support such viral invasion by studying HIV interactions with TGCs in vitro . Our results indicate that isolated primary TGCs express alternative HIV-1 receptors, allowing virion binding but not entry. However, HIV-1 entered...

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PMID: 32999017
DOI: 10.1128/jvi.01145-20

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