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Article

Targeting PIs to improve PTs:a new approach to treating genetic diseases of the proximal tubule.

Kidney international - 1 Oct 2020

Weisz Ora A

Abstract excerpt

Defective recycling of megalin consequent to impaired phosphatidylinositol metabolism has been implicated as a mechanism causing tubular proteinuria in patients with Lowe syndrome. In this issue, Berquez et al. describe an innovative approach using a clinically approved drug to "rebalance" phosphatidylinositols and restore megalin traffic in mouse and cell models of the disease.

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Share to Endocytosis
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Source

Identifiers

PMID: 32998810
DOI: 10.1016/j.kint.2020.06.018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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