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Article

In silico model of mtDNA mutations effect on secondary and 3D structure of mitochondrial rRNA and tRNA in Leber's hereditary optic neuropathy.

Experimental eye research - 1 Dec 2020

Rovcanin Branislav, Jancic Jasna, Samardzic Janko, Rovcanin Marija, Nikolic Blazo, Ivancevic Nikola, Novakovic Ivana, Kostic Vladimir

Abstract excerpt

The Leber's hereditary optic neuropathy (LHON) is a rare disease caused by mitochondrial DNA (mtDNA) mutations. Beside primary mutations, the effect of secondary mtDNA mutations in still unclear. We examined the effect of secondary mtDNA mutations on secondary structure of different mitochondrial RNAs. Whole mitochondrial genome sequence of LHON patients has been obtained from in six non related pedigrees by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32991883
DOI: 10.1016/j.exer.2020.108277

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