Article
Role of the RprY response regulator in P. gingivalis community development and virulence.
Molecular oral microbiology - 1 Dec 2020
Shen Daonan, Perpich John D, Stocke Kendall S, Yakoumatos Lan, Fitzsimonds Zackary R, Liu Chengcheng, Miller Daniel P, Lamont Richard J
Abstract excerpt
Porphyromonas gingivalis expresses a limited number of two-component systems, including RprY, an orphan response regulator which lacks a cognate sensor kinase. In this study, we examined cross-phosphorylation of RprY on tyrosine residues and its importance for RprY function. We show that RprY reacts with phosphotyrosine antibodies, and found that the tyrosine (Y) residue at position 41 is predicted to be solvent...
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