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Article

Safety, Efficacy, and Pharmacokinetics of Almonertinib (HS-10296) in Pretreated Patients With EGFR-Mutated Advanced NSCLC: A Multicenter, Open-label, Phase 1 Trial.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Dec 2020

Yang James Chih-Hsin, Camidge D Ross, Yang Cheng-Ta, Zhou Jianying, Guo Renhua, Chiu Chao-Hua, Chang Gee-Chen, Shiah Her-Shyong, Chen Yuan, Wang Chin-Chou, Berz David, Su Wu-Chou, Yang Nong, Wang Ziping, Fang Jian, Chen Jianhua, Nikolinakos Petros, Lu You, Pan Hongming, Maniam Ajit, Bazhenova Lyudmila, Shirai Keisuke, Jahanzeb Mohammad, Willis Maurice, Masood Nehal, Chowhan Naveed, Hsia Te-Chun, Jian Hong, Lu Shun

Abstract excerpt

INTRODUCTION: Almonertinib (HS-10296) is a novel, third-generation EGFR tyrosine kinase inhibitor (EGFR TKI) that targets both EGFR-sensitizing and T790M resistance mutations. This first-in-human trial aimed to evaluate the safety, efficacy, and pharmacokinetics of almonertinib in patients with locally advanced or metastatic EGFR mutation-positive NSCLC that had progressed after pevious EGFR TKI therapy. METHODS:...

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PMID: 32916310
DOI: 10.1016/j.jtho.2020.09.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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