Article
Liquid phase human papillomavirus genotype analysis of aspirated metastatic head and neck squamous cell carcinoma: Fine needle aspiration supernatant is a rich source of tumor DNA that can increase the diagnostic yield.
Diagnostic cytopathology - 1 Jan 2021
Hao Yansheng, Mehrotra Meenakshi, Lam Hansen, Si Qiusheng, Salem Fadi, Lu Dan, Gitman Melissa, Miles Brett, Posner Marshall, Houldsworth Jane, Westra William H
Abstract excerpt
BACKGROUND: Most patients with human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSC) present with lymph node metastasis. In these patients, fine needle aspiration (FNA) is not only a diagnostic tool, but a means for determining HPV status. HPV status, in turn, is used to determine tumor origin, prognosis, and even guide therapy. Thus, the limited sampling afforded by FNA must be...
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