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Article

A plant-based transient expression system for the rapid production of highly immunogenic Hepatitis E virus-like particles.

Biotechnology letters - 1 Nov 2020

Mardanova Eugenia S, Takova Katerina H, Toneva Valentina T, Zahmanova Gergana G, Tsybalova Liudmila M, Ravin Nikolai V

Abstract excerpt

OBJECTIVE: Hepatitis E virus (HEV) infection is a major cause of acute hepatitis worldwide. The aim of the study is the development of plant expression system for the production of virus-like particles formed by HEV capsid and the characterization of their immunogenicity. RESULTS: Open reading frame (ORF) 2 encodes the viral capsid protein and possesses candidate for vaccine production. In this study, we used...

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PMID: 32875477
DOI: 10.1007/s10529-020-02995-x

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