Article
Functional Connectivity Decreases with Metabolic Stress in Sickle Cell Disease.
Annals of neurology - 1 Nov 2020
Fields Melanie E, Mirro Amy E, Guilliams Kristin P, Binkley Michael M, Gil Diaz Luisa, Tan Jessica, Fellah Slim, Eldeniz Cihat, Chen Yasheng, Ford Andria L, Shimony Joshua S, King Allison A, An Hongyu, Smyser Christopher D, Lee Jin-Moo
Abstract excerpt
OBJECTIVE: Children with sickle cell disease (SCD) experience cognitive deficits even when unaffected by stroke. Using functional connectivity magnetic resonance imaging (MRI) as a potential biomarker of cognitive function, we tested our hypothesis that children with SCD would have decreased functional connectivity, and that children experiencing the greatest metabolic stress, indicated by elevated oxygen...
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